Abstract Search

ea0019p335 | Steroids | SFEBES2009

Epigenetic silencing of the GR and defining the pro-apoptotic actions of GR expression in human cancer cell lines

Kay Paul , Matthews Laura , Sommer Paula , White Anne , Ray David

Although glucocorticoids (Gc) are used to treat a range of pathologies, an individuals response to therapy varies considerably. There is a distinct correlation between certain cell types and steroid sensitivity. Aberrant glucocorticoid receptor (GR) function is well-characterised in lymphoid malignant cells but not small cell lung cancer (SCLC) (DMS79) or osteosarcoma (U2OS) cell lines, which are both Gc resistant.Previously we have shown reduced GR cont...

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ea0038ecp1.2 | (1) | SFEBES2015

Kisspeptin- A ‘key regulator’ of reproductive physiology, integrating limbic circuits with the regulation of reproductive hormones

Comninos Alexander , Anastasovska Jelena , Shah Amar , Wall Matthew , Jayasena Channa , Li Xiaofeng , Abbara Ali , Narayanaswamy Shaku , Nijher Gurjinder , Izzi-Engbeaya Chioma , Demetriou Lysia , Clarke Sophie , Ghatei Mohammad , Bell Jimmy , Matthews Paul , Bloom Stephen , O'Byrne Kevin , Dhillo Waljit

Kisspeptin is a recently identified reproductive hormone which serves as a crucial activator of the HypothalamicPituitaryGonadal (HPG) axis via stimulation of GnRH neurones. We have previously observed that a single kisspeptin injection increases LH pulsatility while twice daily kisspeptin injections can even advance the menstrual cycle. Furthermore, we have demonstrated that kisspeptin restores LH pulsatility in women with hypothalamic amenorrhoea and can potently...

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ea0025oc4.7 | Bone and diabetes | SFEBES2011

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

De Silva Akila , Salem Victoria , Long Christopher J , Makwana Aidan , Newbould Rexford D , Rabiner Eugenii A , Tavare Aniket N , Ghatei Mohammed A , Bloom Stephen R , Matthews Paul M , Beaver John D , Dhillo Waljit S

The physiological post-prandial release of the gut hormones PYY and GLP-1 is implicated in triggering CNS mechanisms underlying satiety. However, the combined effects of PYY and GLP-1 on brain circuits underlying satiety in humans remain unknown.Objective: To determine changes in CNS neuronal activity following single and combined infusions of PYY and GLP-1, using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) in human vol...

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Endocrine Abstracts

Epigenetic silencing of the GR and defining the pro-apoptotic actions of GR expression in human cancer cell lines

Kisspeptin- A ‘key regulator’ of reproductive physiology, integrating limbic circuits with the regulation of reproductive hormones

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

BiosciAbstracts